MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid peptide encoded directly by mitochondrial DNA — making it one of the few known mitochondrial-derived peptides (MDPs). It plays a key role in cellular metabolism and energy homeostasis, acting through pathways related to insulin sensitivity, glucose metabolism, and the cellular stress response. Research has positioned MOTS-c as a potential exercise mimetic and metabolic regulator with emerging interest in longevity science.
Key Benefits
Regulates cellular energy homeostasis through mitochondrial signalling
Enhances insulin sensitivity and glucose metabolism
Activates the AMPK pathway — a master regulator of metabolic adaptation
Exercise mimetic — studied for effects on physical endurance and fat utilization
Emerging research into stress response, metabolic resilience, and longevity
Reconstitution
Add 1mL bacteriostatic water to achieve a 10mg/mL concentration.
Each 0.1mL of solution contains 1mg of MOTS-C.
Swirl gently — do not shake. Allow to fully dissolve.
Storage
Must be refrigerated after reconstitution. Store lyophilized powder below 25°C, away from direct light and moisture. Do not freeze reconstituted solution.
For laboratory research use only. Not for human or veterinary use.